The AMIS Plus national registry collects and analyzes data on patients with acute myocardial infarction in Switzerland in the pre-admission, hospital and followup phases. Emphasis is placed on the evaluation of risk factors, diagnostics, urgent therapy strategies and treatment. AMIS Plus data are important for quality assurance, assessing guidelines, improving compliance with guidelines in clinical practice, verifying whether results of randomized clinical trials are translatable into everyday clinical practice, investigating patient groups not extensively studied in large randomized trials and improving therapeutic strategies.